Der erfolglose Schauspieler Mark scheint nicht vom Glück verfolgt zu sein, als ihn seine langjährige Freundin verlässt. Doch es soll noch schlimmer kommen. Durch eine Verkettung bedauernswerter Umstände sterben in seiner düsteren Dubliner Kellerwohnung im Domino-Prinzip Menschen. Zusammen mit seinem Kumpel Pierce, einem alkoholkranken Drehbuchautoren, übt sich Mark in Katastrophenmanagement...

Waking up to find himself suspended from his office ceiling by what appears to be a web of some description, reluctant hero Cooper soon realises that Earth has become infested with agitated 3ft bugs. Befriending a motley crue of survivors, including the gorgeous Sara to whom he is instantly attracted, Cooper embarks on a quest for the salvation of mankind.

Something evil is stirring in the small mining town of Gold Lick, and it's not happy. Guan-di, the Chinese protector of the dead with a strange affinity for bean curd, has been awakened by reckless teenagers, and now his bloody crusade to wipe out the town's entire population can only be stopped by one man - Bruce Campbell (the guy who starred in all three Evil Dead movies and Bubba Ho-tep), B-move star and deadbeat ex-husband extraordinaire, who's recruited to be their unwitting savior.